A to Z of MS Paroxetine (Seroxat)

Product name

Seroxat. Non branded versions are available.

Paroxetine is an antidepressant drug, one of a class of antidepressants called selective serotonin reuptake inhibitors. It is normally prescribed for depression, particularly accompanied by anxiety.

How paroxetine works

Paroxetine works by increasing the stimulation between some cells in the brain.

How paroxetine is given

Paroxetine is given orally as tablets.

Paroxetine is a long-term treatment. It may take four weeks to feel any beneficial effect. Paroxetine remains in the body for some weeks after an individual has stopped taking the drug, therefore, individuals should not stop abruptly but taper off treatment with a doctor's advice.

Side effects

Common side effects include decrease in sexual drive or ability, headache, nausea, problems urinating, change in appetite, unusual tiredness or weakness, tremor, trouble sleeping, anxiety, agitation, nervousness, changes in vision, fast or irregular heartbeat, burning or prickly sensations, vomiting. Most of these side effects are transitory and should wear off as an individual adjusts to the drug.

Contraindications

Paroxetine should not be taken by people with reduced kidney or liver function, or history of some types of mental health problems. It should also not be taken during pregnancy or when still breastfeeding.

Paroxetine can interact with other medications that affect the central nervous system, notably carbamazepine, phenytoin and diazepam, affecting the rate at which they are absorbed.

Reference

Ehde DM, et al.
Efficacy of paroxetine in treating major depressive disorder in persons with multiple sclerosis.
General Hospital Psychiatry 2008;30(1):40-48.
abstract

Patient Information Leaflets

Seroxat (EMC website)

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